In this study we examine variables from an airline's Flight Data Monitoring system in relation to scheduling and working conditions variables. The study is unique and can contribute with new and important knowledge about outcomes not only in terms of health and aviation safety but also in economic and environmental aspects. Deviations from normal values in the FDM system, such as e.g. a too steep approach, constitutes, not only a safety risk but also costs in fuel, both economically and environmentally. By identifying key factors underlying these events, we hope to be able to work proactively with prevention and modification beneficial for both individuals, airlines and the society in the form of safe, efficient and robust air travel.